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ponse in the presence of the drug. Data are expressed as the mean 6 standard deviation. Statistical significance was assessed using paired Student's t-tests, with P,0.05 considered significant.Light stimulationLight from a mercury arc lamp illuminated an aperture that was focused on the retina from above, through the 4X objective of the microscope. The image produced on the retina was either amGl
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s presentations. Intensity-response curves of RGCs were fitted with a sigmoidal dose-response (variable slope), using SigmaPlot 10.0 (SPSS, Chicago, IL). Three parameters were measured from the curve fits: maximum peak response, dynamic operating range, and light sensitivity. The maximum peak response was simply the result from the fit of data points. The dynamic operating range was defined as th
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