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On electron micrograph reported extensive cell wall and cell membrane lysis processes in DM3-treated pneumococcal cells. Together with the absence of differential autolysin expression in DM3-treated group in this study, it is suggested that other lytic mechanisms could be involved. In addition, membrane and cell wall associated structural components and transport mechanisms were greatly affected
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Require further optimization. In addition to viral vectors, recombinant bacterial carriersRequire further optimization. In addition to viral vectors, recombinant bacterial carriers, derived from lactic acid bacteria, Salmonella and L. monocytogenes strains, have been used extensively as delivery systems being able to stimulate both systemic [29,30] and mucosal immune responses .GENE DELIVERY
He higher susceptibility of PRSP than PSSP to DM3. This is essentially one of our main objectives in designing DM3 ?a novel drug possessing high antibacterial activity against the antibiotic-resistance strains. The gene expression profile of SP17 (PRSP strain used in this study) was heavily affected by DM3 and DM3PEN which was in sharp contrast to the gene expression profile of SP27 (PSSP strain
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